Biohacker Bryan Johnson Calls Supplements an 'Influencer Heist' and Money Waster

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Biohacker Bryan Johnson Criticizes AG1 Supplements, Claims No Clinical Benefit

Biohacker Bryan Johnson has raised concerns about the popular Athletic Greens (AG1) supplement, stating that it offers "no clinical benefit." The 48-year-old biohacker, who claims to be more than a decade younger biologically, has shared his views on the supplement, which is marketed as a comprehensive health booster. AG1 is a powder supplement that promises to support gut health, enhance energy production, improve immune function, and fill nutritional gaps.

Johnson, known for taking over 100 supplements daily to lower his biological age, has advised people to cancel their AG1 subscriptions. He pointed to a resurfaced 2024 clinical trial of the product, which involved 30 healthy adults. Half of the participants took AG1 for four weeks, while the other half used a placebo. Researchers collected stool samples and assessed digestive health through questionnaires.

The study found minor improvements in the gut microbiome among those who took AG1. However, these improvements were not statistically significant compared to the placebo group, suggesting that more long-term research is needed to determine any real benefits. Johnson argues that the results indicate the supplement lacks substantial value and recommends cheaper alternatives: chicory inulin and resistant starch.

These alternatives are believed to support gut health, balance blood sugar, and aid in weight management, though scientific evidence remains limited. AG1 costs $79 per month with a subscription or $99 for a one-time purchase, providing 30 servings. In contrast, chicory inulin ranges from $13 to $25 for a 16-ounce container, while resistant starch is around $20 to $40 for the same amount, lasting roughly a month. This makes the cost per serving significantly lower for the alternatives.

Johnson emphasized on social media: "I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit. This has been obvious for years. AG1 has no real product substance and is fundamentally an influencer heist."

In response, AG1 addressed the claims on social media, stating that the study "doesn’t say what you’re claiming." The company highlighted that the trial showed improved nutrient status and digestive quality of life, consistent with multiple randomized, placebo-controlled trials. AG1 also mentioned that its research program includes several studies demonstrating positive impacts, emphasizing transparency and quality.

The clinical trial referenced by Johnson was published in the Journal of the International Society of Sports Nutrition in 2024. It involved 15 men and 15 women aged 18 to 50, who completed questionnaires about their digestive health, provided stool samples, and underwent blood work. The study found that AG1 increased the levels of several beneficial probiotic species, including Lactobacillus acidophilus, Bifidobacterium bifidum, Lactococcus lactis, and Acetatifactor sp. However, the results were not statistically significant, and further research is needed, especially in populations with gastrointestinal issues.

AG1’s website highlights this trial and several earlier studies to support its claims about improving digestion, immune health, energy, and gut health. Johnson, however, points to chicory inulin and resistant starch as more effective and affordable options.

Chicory inulin is a natural soluble fiber that dissolves in water, forming a gel-like substance during digestion. It helps slow digestion and promote fullness. Studies suggest it supports regular bowel movements and blood sugar control. For example, a four-week study in 44 adults with constipation found that taking 12 grams of chicory inulin daily led to softer stools and more frequent bowel movements compared to a placebo.

Resistant starch, a type of carbohydrate that resists digestion in the small intestine, ferments in the large intestine, feeding healthy bacteria and regulating blood sugar. A 2022 review indicated that resistant starch may improve insulin sensitivity and fullness, but noted it is not well-studied. Higher doses of either supplement can cause bloating, abdominal pain, loose stools, and gas.